Xinliu River is the boundary river between Shanghai and Jiangsu Province. The Jialiu Highway is a high-grade highway connecting Jiading County of Shanghai to Liuhe Town of Jiangsu Province, with a total length of 16 km for its second-phase project. The main bridge, Xinliuhe Bridge, was constructed using the precast segmental method with integral assembly, and multiple new prestressing technologies were applied. This paper mainly introduces the new prestressing-related technologies involved in the design and construction of this bridge.