Based on the 170 m span network hanger tied-arch bridge of the Guangming Road Guohe Bridge in Bozhou city, structural design and mechanical characteristic analysis are carried out in this study to address the problems associated with traditional vertical hangers in medium-to-large span tied-arch bridges, namely, their susceptibility to slackness, insufficient stiffness, and inadequate stability. The main bridge is a single-span 170 m network hanger tied-arch bridge. The main girder is a double-box steel–concrete composite girder, and the arch rib is an octagonal steel box section without transverse bracing. The hangers are arranged in a crossed network pattern, and the substructure adopts a friction pendulum seismic isolation system. Static, stability, and seismic calculations are performed using the finite element method. The results show that the network hangers can significantly improve the internal force distribution of the main girder and arch rib, reducing both bending moments and deflections. The structural stiffness and stability satisfy the code requirements. The seismic isolation design effectively reduces the seismic response of the piers, and the seismic performance meets the relevant standards. This bridge type demonstrates good technical feasibility and economic rationality for wide urban bridges with spans of 150–200 m and can serve as a reference for similar projects.