In the actual construction process, there are many factors that affect the alignment and structural perfor-mance of bridges, and their influence on bridge structures should not be underestimated. This paper conducts a simulation analysis of a large-span hybrid girder rigid frame bridge using Midas/Civil2020. Deflection values in the completed state are used as evaluation criteria. Sensitivity analysis is performed on construction control parameters such as the self-weight of the girder, girder stiffness, prestressing pa-rameters, environmental temperature, and unbalanced basket weight. This analysis determines the degree of influence of these parameters on the bridge structure, providing a basis for bridge monitoring during actual construction and offering relevant monitoring recommendations.