With the development of modern long-span cable-stayed bridges, due to the parallel strand cable (PSC) being assembled on-site strand by strand, which has the advantages such as no need for large-scale equipment for cable-making, delivery, hoisting, traction, tensioning, and the corrosion protection of the cable is excellent, it is more and more favored by designers. As load-bearing components, the stay cables are known as the life cable of the cable-stayed bridge. Its reliability and durability are the key factors that determine the safety and the service life of the cable-stayed bridge. In accordance with the requirements specified in international recommendations, in-depth research has been carried out on cable fatigue, anti-corrosion, and vibration control to optimize OVM250 PSC system. All research results have been successfully applied to cable stayed bridge projects.