In order to develop the main cable with high fatigue resistance that can meet the requirements of the FAST project, the fatigue performance of the main cable of the cable network was innovated, and the innovative design and improvement of the raw material, anchor structure, cable body structure and key manufacturing process were verified through the fatigue test. The experimental results confirmed that the maximum fatigue stress range of the improved and innovative main cable of the cable network could withstand could reach 50 0MPa, which meets the requirements of high fatigue resistance of FAST project.