This paper studies the waterproofing and anti-corrosion technology of the anchor head under the suspension cable of Liede Bridge in view of the diseases and characteristics of the suspension cable that occurred at the anchor head under the suspension cable. A new sealed waterproof structure is adopted and indoor and field tests are carried out respectively. According to the results of indoor and field tests, scientific and reasonable maintenance and management countermeasures are formulated and popularized in the treatment of diseases at the anchor head under Liede Bridge, achieving good results.