Short tower cable-stayed bridges generally use round tube-type split wire pipe saddles, and adopt the structural form of anti-skid keys cross-anchoring when achieving the function of single anti-skid and single replacement of cables. However, when the unbalanced force on one side of the cable is high, the arrangement of cross-anchoring of anti-skid keys cannot meet the working condition of large unbalanced force on one side. A one-sided bidirectional anti-skid replaceable anchorage system is proposed. Taking the Taiwan Xiaobantian short tower cable-stayed bridge project as the background, this paper studies the application of this anchorage system in short tower cable-stayed bridges. Through finite element analysis, physical simulation tests, saddle anti-skid force tests, segment model tests, cable replacement tests, etc., the problem of single anti-skid and single replacement of cables under the working condition of unbalanced force on one side of the cable is solved, and it is successfully applied in Taiwan Xiaobantian Bridge.