Based on the design and analysis of building isolation method in high intensity earthquake area, taking a reinforced concrete frame structure as an example, the finite element analysis software ETABS was used to conduct dynamic analysis of the seismic isolation technology using rubber bearings, and the time-history analysis results were compared. The results show that compared with the seismic frame structure, the period of the bottom isolation frame structure is longer, the layer shear force, displacement, and the bottom layer All the axial forces are smaller, so it is proved theoretically that the seismic isolation bearing can effectively reduce the adverse effects of seismic loads on the structure and improve the safety of the structure.