A computer-controlled synchronous lifting scheme is often adopted for the integral lifting construction of large-scale structures. In this study, a four-lifting-point mechanical model was constructed which revealed the coupling relationship between the load and displacement of lifting points. It was further clarified that the relative stiffness of lifting points is the core factor affecting the asynchrony effect. Calculations for displacement asynchrony and load asynchrony conditions revealed that when the relative stiffness of lifting points is large, a control strategy primarily based on load synchronization is preferred; in contrast, when the relative stiffness is small, a control strategy primarily based on displacement synchronization is preferred. Furthermore, for lifting structures with complex conditions, a dual-objective control must be adopted to ensure lifting safety. The research results can provide a theoretical basis and technical reference for synchronous control and safe integral lifting construction of large-scale structures.