Using a practical engineering project as an example, this study analyzes a self-anchored suspension bridge under two different restraining systems: a fully floating system and a semi-floating system. This investigation focuses on static performance, overall stability, wind resistance, and seismic behavior. The static characteristics and dynamic responses of the self-anchored suspension bridge under different restraining systems are obtained, and the influence of the tower–girder constraint conditions on the mechanical behavior of the structure is discussed.