In the design scheme of a bridge with external prestressing tendons and hybrid internal and external tendons, the internal tendons can bear the load in cantilever casting construction, the external tendons can bear the superimposed dead load and the service load, and the external prestressing tendons are easy to inspect and replace in the service stage. However, in the design of prestressing tendons and hybrid tendons, different tendon arrangement schemes will lead to differences in the layout and number of internal and external prestressing tendons and determine the stress state of the bridge. This paper optimized different tendons in an engineering project during the construction process based on the principle that the internal tendons bear the load in the construction stage while the external tendons bear the superimposed dead load and the service load, highlighted the arrangement schemes of different internal prestressing tendons and the corresponding design of external prestressing tendons, and determined the final bridge design scheme and bridge stress state. The relevant design process can provide references for similar prestressed con-tinuous girder or continuous rigid-frame bridges with hybrid tendons.