With the rapid development of bridge technology, China has mature experience in the closing construction technology of high-pier and long-span continuous rigid frame girder Bridges, but the selection of closing sequence and closing mode is still the two major problems at present. Based on the background of Qinhe Bridge, this paper studies the influence of several closing methods and closing sequence on the post-completion structure stress and their respective applicable conditions through comparative calculation It provides reference for bridge construction in the future.