The main bridge of Ningbo Bund Bridge adopts a special cable-stayed bridge structure with a single tower and four cable planes with a main span of 225m, and the approach bridge adopts a prestressed concrete continuous beam structure. This paper focuses on the application of prestressed engineering technology of the main bridge of the Bund Bridge, such as the cable-stay and anchorage system, the post-anchor prestressing and suspension anchorage system, the steel-concrete connection node of the tower pier, the design of the prestressed concrete continuous box girder of the approach bridge, and the prestressed tension control during the construction of the tower rotation, which has certain reference value for similar projects.