Taking the service life of Hong Kong–Zhuhai–Macau Bridge for 120 years as an example, this paper makes quantitative analysis on the carbonization process and chloride ion invasion process of concrete structure, and expounds in detail the measures to improve its durability. At the same time, it expounds in detail the anti-corrosion measures for steel structure components such as steel box girder, bridge deck, cable stayed cable, steel anchor beam, steel anchor box, etc., which provides a certain reference for the durability design of bridges in the same environment