The corrosion protection of rock and soil prestressed anchor cable is very important, once stress corrosion occurs, it may cause fatal damage. Many projects in our country pay more attention to the application of anchoring force, but lack of understanding of corrosion damage and anti-corrosion of anchoring cables. This paper discusses the corrosion mechanism and characteristics of rock-soil prestressed anchor cables, compares the difference of anti-corrosion requirements of rock-soil anchorage codes at home and abroad, and puts forward some anti-corrosion suggestions for rock-soil prestressed anchor cables which are suitable for the characteristics of anchorage engineering in China.