Wuhan Yangluo Yangtze River Bridge is a main span 1280m suspension bridge. The north anchorages adopt sloping large excavation deep buried expanded foundation solid web anchor weight type anchor; south anchorages adopt supporting excavation deep buried circular expanded foundation frame anchor weight type anchor, the pit project adopts 73m outer diameter, 1.5m wall thickness, 61.5m depth, maximum excavation depth of 45m circular diaphragm wall plus liner support structure type; in the country for the first time to study and apply the exchangeable pre-stressing anchorage system. This paper summarizes the overall structure of anchor design, the study of interchangeable prestressing anchorage system and its design technology characteristics.