Pointing out that a unidirectional longitudinal slope cable-stayed bridge is a new type of bridge that is different from a bidirectional longitudinal slope cable-stayed bridge. Due to its unidirectional slope, its mechanical properties, stability during construction, and other aspects are different from those of a bidirectional longitudinal slope cable-stayed bridge. Analyzed the characteristics and advantages of one-way slope cable-stayed bridges, and explored the optimal slope selection, optimal system, number of cable force adjustments, nonlinear analysis, and other contents of one-way slope cable-stayed bridges