The full-scale model tests of two large cable-stayed Bridges (Nancha Bridge of Nanjing Yangtze River No. 2 Bridge and North Cha Bridge of Runyang Yangtze River Highway Bridge) are briefly introduced, and the anti-cracking safety factor and ultimate bearing capacity of cable pylon anchoring area are studied. At the same time, the rational arrangement of the prestressed cables in the anchoring area of the cable tower and the simulation effect of the cable tower segment model on the whole cable tower are also studied, which has theoretical guiding significance and practical value for the cable tower design of cable-stayed bridge.